I have a Presonus Quantum 2 interface. I am using outputs 1-2 to drive my nearfield monitors. The same signal goes to the headphone socket on the front of the audio interface. In Sonarworks I have a headphone profile and a monitor profile to select from depending on which I am using, and they are both routed to that main set of outputs. So far so good!
Now, I am planning to connect a second set of speakers to outputs 3-4 on the audio interface. I would like to be able to have a third profile for this in Sonarworks, which would have its own measurement profile for those speakers AND which would automatically route the signal to 3-4 instead of 1-2 when selected.