Sonarworks Reference 4 Headphone & Studio Edition:
Windows: Windows 7 or later (32 & 64 bit)
Mac: OS X 10.12 or later*
Measure software & Reference plug-in will work on OS X 10.9 or later
*Reference 4.3 Systemwide is fully supported starting from macOS Sierra (10.12) because on it the system allows setting an external audio clocking source. This improves audio signal sync between virtual and physical audio devices.