Sonarworks Reference 4 Headphone & Studio Edition:
Windows 7 or later (32 & 64 bit)
OS X 10.12 or later*
*Starting from Reference 4.3, Systemwide app is fully supported on macOS 10.12 Sierra or later. This is because starting from macOS 10.12, the OS allows setting an external audio clocking which improves audio signal sync between virtual and physical audio devices.
Reference Measure app and the DAW plugin are still fully supported starting from macOS Mavericks (10.9) or later.
Reference 4.4 is also fully supported on macOS 10.15 Catalina.