Systemwide not launching after an update is an issue that can happen on both macOS and Windows operating systems. Usually, it is caused by settings that can't be migrated between the old and the new Systemwide version.
To solve the problem please find the Systemwidecfg.db file in the following location:
Windows: C:\Users\your username\AppData\Local\Sonarworks\Reference 4\Systemwide\Systemwidecfg.db
macOS: ~/Library/Sonarworks/Reference 4/Systemwide/Systemwidecfg.db
Once you find the file, remove it from the folder or delete it. Systemwide should launch after this action. If something is still not working as it should, please contact our support team.